Dr. Nathan Ledeboer works at the Medical College of Wisconsin as Medical Director of Clinical Microbiology. Dr. Ledeboer’s primary responsibility is for the medical and technical oversight of the Clinical Microbiology and Molecular Diagnostics Laboratories. In this role he oversees development and implementation of new assays, oversees and sign out all testing performed in these laboratories, and consults with physician colleagues regarding test results and selection.

Research Interests

• Development of rapid molecular techniques for detection of infectious diseases

• Host Response to Infection

• Combining Digital Imaging and Artificial Intelligence

• Molecular detection and epidemiology of Respiratory Viruses

• Antimicrobial resistance

Publications

• Use of a cohorting-unit and systematic surveillance cultures to control a Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae outbreak. (Reeme AE, Bowler SL, Buchan BW, Graham MB, Behrens E, Singh S, Hong JC, Arvan J, Hyke JW, Palen L, Savage S, Seliger H, Huerta S, Ledeboer NA, Kotay S, Mathers AJ, Cooper VS, Mustapha MM, Mettus RT, Doi Y, Munoz-Price LS.) Infect Control Hosp Epidemiol. 2019 07;40(7):767-773 PMID: 31084655 SCOPUS ID: 2-s2.0-85065637314 05/16/2019

• Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges.(Gunsolus IL, Sweeney TE, Liesenfeld O, Ledeboer NA.) J Clin Microbiol. 2019 Jul;57(7) PMID: 31043466 PMCID: PMC6595443 SCOPUS ID: 2-s2.0-85068514285 05/03/2019

• The relevance of sink proximity to toilets on the detection of Klebsiella pneumoniae carbapenemase inside sink drains. (Buchan BW, Graham MB, Lindmair-Snell J, Arvan J, Ledeboer NA, Nanchal R, Munoz-Price LS.) Am J Infect Control. 2019 01;47(1):98-100 PMID: 30172608 SCOPUS ID: 2-s2.0- 85052737901 09/03/2018

• Multicenter evaluation of the Alere™ i influenza A&B assay using respiratory specimens collected in viral transport media (Hassan F, Crawford J, Bonner AB, Ledeboer NA, Selvarangan R.) Diagn Microbiol Infect Dis. 2018 Dec;92(4):294-298 PMID: 30077505 SCOPUS ID: 2-s2.0-85050811176 08/06/2018

• Clinical Evaluation of the iCubate iC-GPC Assay for Detection of Gram-Positive Bacteria and Resistance Markers from Positive Blood Cultures. (Granato PA, Unz MM, Widen RH, Silbert S, Young S, Heflin KL, Conover MS, Buchan BW, Ledeboer NA.) J Clin Microbiol. 2018 09;56(9) PMID: 29899000 PMCID: PMC6113461 SCOPUS ID: 2-s2.0-85052491577 06/15/2018

• Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis. (Pancholi P, Carroll KC, Buchan BW, Chan RC, Dhiman N, Ford B, Granato PA, Harrington AT, Hernandez DR, Humphries RM, Jindra MR, Ledeboer NA, Miller SA, Mochon AB, Morgan MA, Patel R, Schreckenberger PC, Stamper PD, Simner PJ, Tucci NE, Zimmerman C, Wolk DM.) J Clin Microbiol. 2018 04;56(4) PMID: 29305546 PMCID: PMC5869823 SCOPUS ID: 2-s2.0-85044779516 01/07/2018

• Effective utilization of C. difficile PCR and identification of clinicopathologic factors associated with conversion to a positive result in symptomatic patients. (Mostafa ME, Flynn T, Hartley CP, Ledeboer NA, Buchan BW.) Diagn Microbiol Infect Dis. 2018 Apr;90(4):307-310 PMID: 29290473 SCOPUS ID: 2-s2.0-85039550113 01/02/2018

• Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Use with Positive Blood Cultures: Methodology, Performance, and Optimization. (Faron ML, Buchan BW, Ledeboer NA.) J Clin Microbiol. 2017 12;55(12):3328-3338 PMID: 28855303 PMCID: PMC5703799 SCOPUS ID: 2-s2.0-85036667185 09/01/2017

• A Novel Protocol Obviates Endoscope Sampling for Carbapenem-Resistant Enterobacteriaceae: Experience of a Center with a Prior Outbreak. (Smith ZL, Dua A, Saeian K, Ledeboer NA, Graham MB, Aburajab M, Ballard DD, Khan AH, Dua KS.) Dig Dis Sci. 2017 11;62(11):3100-3109 PMID: 28681083 SCOPUS ID: 2-s2.0- 85021843628 07/07/2017

• Evaluation of Copan FecalSwab as Specimen Type for Use in Xpert C. difficile Assay. (Mashock MJ, Faron ML, Buchan BW, Ledeboer NA.) J Clin Microbiol. 2017 10;55(10):3123-3129 PMID: 28794179 PMCID: PMC5625397 SCOPUS ID: 2-s2.0-85030127876 08/11/2017

• Impact of Organism Identification Method on Central Line-Associated Bloodstream Infection Designation. (Gomez EJ, Roberts AL, Robinson DP, Alby K, Ledeboer NA, Doern CD, Lander DW, Bearman G, Sullivan KV.) Infect Control Hosp Epidemiol. 2017 08;38(8):1007-1009 PMID: 28633680 SCOPUS ID: 2-s2.0-85021144054 06/22/2017

• Multicenter Evaluation of the Bruker MALDI Biotyper CA System for the Identification of Clinically Important Bacteria and Yeasts. (Wilson DA, Young S, Timm K, Novak-Weekley S, Marlowe EM, Madisen N, Lillie JL, Ledeboer NA, Smith R, Hyke J, Griego-Fullbright C, Jim P, Granato PA, Faron ML, Cumpio J, Buchan BW, Procop GW.) Am J Clin Pathol. 2017 Jun 01;147(6):623-631 PMID: 28505220 SCOPUS ID: 2-s2.0-85031705467 05/16/2017